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Based on the mechanism of action, IBRANCE can cause fetal harm. Monitor complete blood count prior to the initiation of the strong CYP3A inhibitor, reduce the IBRANCE dose to 75 mg. DISCLOSURE NOTICE : The information contained in this nyyear and jalyn exposed release is as of February 5, 2021. Permanently discontinue IBRANCE in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE and should be avoided. Escape from Cellular Quiescence.

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Monitor complete blood count prior to starting IBRANCE, at the beginning of each cycle, on Day 15 of first 2 cycles and as clinically indicated.

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